IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS VACCINE COMPOSED OF GENETICALLY INACTIVATED PERTUSSIS TOXIN COMBINED WITH FILAMENTOUS HEMAGGLUTININ AND PERTACTIN IN INFANTS AND CHILDREN
- Autori: PODDA A; CARAPELLA DE LUCA E; TITONE L; CASADEI A.M; A. CASCIO; BERTALINI M; VOLPINI G; PEPPOLONI S; MARSILI I; NENCIONI L; RAPPUOLI R
- Anno di pubblicazione: 1993
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/415760
Abstract
We studied the immunogenicity of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin (PT-9K/129G), filamentous haemagglutinin, and a 69-kilodalton protein, pertactin, in 30 children aged 12 to 24 months and in 80 infants aged 2 to 4 months. A significant increase of the neutralizing titer and of the titers against pertussis toxin, filamentous hemagglutinin, and pertactin, as determined by enzyme-linked immunosorbent assay, was achieved after three doses of vaccine in all the children; a significant increase of these antibody titers was obtained in 100%, 96.1%, 93.5%, and 98.7% of the infants, respectively.