TREATMENT OF VISCERAL LEISHMANIASIS IN CHILDREN USING LIPOSOMAL AMPHOTHERICIN B
- Autori: DI MARTINO L; DAVIDSON R.N; GIACCHINO R; SCOTTI S; RAIMONDI F; CASTAGNOLA E; TASSO L; A. CASCIO; GRADONI L; GRAMICCIA M; PETTOELLO-MANTOVANI M; BRYCENSON DM
- Anno di pubblicazione: 1997
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/415811
Abstract
We used liposomal amphotericin B as first-choice treatment of visceral leishmaniasis in 106 immunocompetent children who acquired the infection in a temperate region of southern Europe (Italy) where Leishmania infantum visceral leishmaniasis is endemic. The aim of the study was to identify the minimum total dose of liposomal amphotericin B needed to cure the infection in children and reduce the period of hospitalization. We conclude that the optimal regimen in immunocompetent children with L. infantum visceral leishmaniasis to be a total dose of 18 mg/kg of liposomal amphotericin B (3 mg/kg per day for 5 days, followed by 3 mg/kg administered as an outpatient regimen on day 10).