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Haemophagocytic syndrome and rickettsial diseases. A new case and systematic review of the literature

  • Autori: Cascio, A.; Giordano, S.; Dones, P.; Venezia, S.; Iaria, C.; Ziino, O.
  • Anno di pubblicazione: 2011
  • Tipologia: Articolo in rivista
  • OA Link:


Haemophagocytic lymphohistiocytosis is a rare but potentially fatal disease resulting from dysregulated activation and proliferation of lymphocytes. We present a case of haemophagocytic syndrome occurring in a 5-year-old Italian boy as a complication of Mediterranean spotted fever. The characteristics of this case have been analysed and contextualized among those of another 15 cases of haemophagocytic syndrome associated with rickettsial diseases found through a systematic review of the international literature.