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ANTONIO CASCIO

The role of endosomal toll-like receptors in bacterial recognition

  • Autori: Biondo, C.; Mancuso, G.; Beninati, C.; Iaria, C.; Romeo, O.; Cascio, A.; Teti, G.
  • Anno di pubblicazione: 2012
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/379677

Abstract

BACKGROUND: Infections caused by extracellular Gram positive bacteria are still a major health problems. Better understanding of the mechanisms underlying immune responses to these organisms is key to develop pharmacological agents, including vaccines, to control these infections. OBJECTIVE AND PERSPECTIVES: The objective of this review is to highlight the importance of nucleic acid-sensing, intracellular Toll-like receptors in innate immune recognition and in host defenses against extracellular bacteria. CONCLUSIONS: Toll-like receptors 7 and 9 have a major role in inducing host-protective type I interferon responses in conventional dendritic cells in response to streptococci and other extracellular gram positive bacteria. Moreover an as yet unidentified MyD88-dependent receptor is likely responsible for proinflammatory cytokine induction in response to these pathogens.