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Recurrent leishmaniasis in kidney transplant recipients: Report of 2 cases and systematic review of the literature

  • Autori: Simon, I.; Wissing, K.; Del Marmol, V.; Antinori, S.; Remmelink, M.; Nilufer Broeders, E.; Nortier, J.; Corbellino, M.; Abramowicz, D.; Cascio, A.
  • Anno di pubblicazione: 2011
  • Tipologia: Articolo in rivista (Articolo in rivista)
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The characteristics of 8 episodes of leishmaniasis with atypical manifestations in 2 Italian kidney transplant recipients are analyzed and contextualized among those of 52 other episodes of leishmaniasis observed in 19 transplant recipients found through a systematic review of the international literature. In all the patients, the initial episode was visceral leishmaniasis, which was associated with mucocutaneous involvement in 2 cases. With the exception of 1 case of post kala-azar dermal leishmaniasis, 2 episodes of Leishmania endophthalmitis, and 3 episodes of mucocutaneous leishmaniasis, all the recurrences were characterized by visceral involvement. The potential role of polymerase chain reaction in monitoring the infection, the importance of a long follow-up, the potential benefit of chemoprophylaxis, and the therapeutic challenges are discussed. © 2011 John Wiley & Sons A/S.