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MARIA VALERIA RAIMONDI

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action

  • Autori: Raffa, D; Maggio, B; Raimondi, MV; Cusimano, MG; Amico, G; Carollo, A; Conaldi, PG; Bai, R; Hamel, E; Daidone, G
  • Anno di pubblicazione: 2013
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: 2-cinnamamidobenzamides, 2-(3-phenylpropiolamido)benzamides, 2-(3-phenylpropanamido)benzamides, antiproliferative activity, apoptosis
  • OA Link: http://hdl.handle.net/10447/93475

Abstract

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).