Thromboelastographic profiles as a tool for thrombotic risk in digestive tract cancer
- Autori: Papa, M L; Capasso, F; Pudore, L; Torre, S; Mango, S; Russo, V; Delrio, P; Palaia, R; Ruffolo, F; d'Eufemia, M D; De Lucia, D; Napolitano, M; Di Micco, P; Parisi, V
- Anno di pubblicazione: 2007
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Aged; Area Under Curve; Blood Coagulation Tests; Carcinoma; Case-Control Studies; Female; Humans; Kinetics; Male; Middle Aged; Reference Values; Risk Factors; Sex Factors; Stomach Neoplasms; Thrombelastography; Thromboembolism
- OA Link: http://hdl.handle.net/10447/350512
Abstract
Quantification of the magnitude of thrombotic risk associated with malignancy and with anti-cancer therapy is indispensable to use anticoagulant drugs which selectively interfere with haemostatic mechanisms protecting patients from venous thromboembolism (VTE) and probably from tumor progression. However, none of activation coagulation markers has any predictive value for the occurrence of the thrombotic events in one individual patient. Current clotting methods can't reveal the overall dynamic clot formation; in contrast thromboelastographic methods specifically assess overall coagulation kinetics and its strength in whole blood.