Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010
- Autori: Colafigli, M; Torti, C; Trecarichi, E; Albini, L; Rosi, A; Micheli, V; Manca, N; Penco, G; Bruzzone, B; Punzi, G; Corsi, P; Parruti, G; Bagnarelli, P; Monno, L; Gonnelli, A; Cauda, R; Di Giambenedetto, S; Mancuso, S
- Anno di pubblicazione: 2012
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance, Viral; Evolution, Molecular; Microbiology (medical); Infectious Diseases
- OA Link: http://hdl.handle.net/10447/215818
Abstract
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.