MAGNESIUM, OXIDATIVE STRESS AND AGING MUSCLE

Abstract

Magnesium (Mg) deficiency, aside from having a negative impact on the energy production pathways required by the mitochondria to generate ATP, also reduces the threshold antioxidant capacity of the aging organism and its resistance to free-radical damage. Mg acts as an antioxidant against free radical damage of the mitochondria. Chronic Mg deficiency results in excessive production of oxygen-derived free radicals and low-grade inflammation. Chronic inflammation and oxidative stress have been identified as pathogenic factors in several age-related conditions. Aging is often associated with Mg inadequacy, muscle loss and sarcopenia. Although the importance of magnesium as a determinant of muscle performance in young athletes is well-established, its role in maintaining muscle integrity and function in older adults is largely unknown. Serum magnesium concentration is an independent correlate of muscle performance in older persons. Whether magnesium supplementation would prevent sarcopenia and improve muscle function in the elderly remains to be demonstrated.