DIGITAL SPATIAL PROFILING OF DIFFUSE LARGE B‐CELL LYMPHOMAS REVEALS STING AS AN IMMUNE‐RELATED DETERMINANT OF SURVIVAL AFTER R‐CHOP THERAPY
- Autori: Hoppe, M. M; Fan, S; Jaynes, P; Peng, Y; Liu, X; De Mel, S; Poon, L; Chan, E; Lee, J; Chee, Y. L; Ong, C. K; Tang, T; Lim, S. T; Chng, W. J; Grigoropoulos, N. F; VanSchoiack, A; Bertolazzi, G; Ng, Siok‐B; Tripodo, C; Jeyasekharan, A. D
- Anno di pubblicazione: 2021
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/631256
Abstract
Alterations in the immune infiltrate of Diffuse Large B‐ Cell Lymphoma (DLBCL) are known to influence survival. However, the relative prognostic importance of different immune components is not clear. Digital spatial profiling (DSP) enables highly multiplexed protein‐based measurement of immune markers in a single tissue section. Here, we applied DSP to evaluate the prognostic significance of immune markers in R‐CHOP treated DLBCL.