Correlation between FIX genotype and pharmacokinetics of Nonacog alpha according to a multicentre Italian study
- Autori: Morfini, M.; Dragani, A.; Paladino, E.; Radossi, P.; Di Minno, G.; Mazzucconi, M.; Rossetti, G.; Barillari, G.; Napolitano, M.; Tagariello, G.
- Anno di pubblicazione: 2016
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: DNA Recombinant proteins; factor IX; genotype; haemophilia B; pharmacokinetics
- OA Link: http://hdl.handle.net/10447/174312
Abstract
Pharmacokinetic (PK) studies on recombinant FIX concentrate, Nonacog alpha, were conducted with different sampling time designs which gave rise to not complete and homogenous outcomes. In addition, patient's FIX genotype/PK relationship has never been investigated.