30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study
- Autori: Wong G.Y.M.; Wadhawan H.; Roth Cardoso V.; Bravo Merodio L.; Rajeev Y.; Maldonado R.D.; Martinino A.; Balasubaramaniam V.; Ashraf A.; Siddiqui A.; Al-Shkirat A.G.; Mohammed Abu-Elfatth A.; Gupta A.; Alkaseek A.; Ouyahia A.; Said A.; Pandey A.; Kumar A.; Maqbool B.; Millán C.A.; Singh C.; Pantoja Pachajoa D.A.; Adamovich D.M.; Petracchi E.; Ashraf F.; Clementi M.; Mulita F.; Marom G.A.; Abdulaal G.; Verras G.I.; Calini G.; Moretto G.; Elfeki H.; Liang H.; Jalaawiy H.; Elzayat I.; Das J.K.; Aceves-Ayala J.M.; Ahmed K.T.; Degrate L.; Aggarwal M.; Omar M.A.; Rais M.; Elhadi M.; Sakran N.; Bhojwani R.; Agarwalla R.; Kanaan S.; Erdene S.; Chooklin S.; Khuroo S.; Dawani S.; Asghar S.T.; Fung T.K.J.; Omarov T.; Grigorean V.T.; Boras Z.; Gkoutos G.V.; Singhal R.; Mahawar K.; Madhok B.; Graham Y.; Donohoe C.; Reira M.; Vish Y.K.S.; Jain R.; Popat S.; Boddy A.; Jain V.; Marques C.N.; Wazir I.; Pereira J.P.S.; Abouelazayem M.; Viswanath N.; Sarodaya V.; Bala V.; Homayoon R.; Dogjani A.; Tidjane A.; Antozzi L.; Hong J.; Dash A.K.; Chokshi A.; Wietzycoski C.R.; Petkov P.; Mbonicura J.C.; Yang W.; Zuluaga M.; Kraljik D.; Lincango Naranjo E.P.; Elghadban H.M.; Diaz A.; Gerogiannis I.; Mohammed A.; Lazaros L.; Bhasker A.G.; Kermansaravi M.; Mahdi A.S.; Kayyal M.Y.; Frattini F.; Ferrara F
- Anno di pubblicazione: 2025
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/674967
Abstract
Objective:This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.Background:Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.Methods:A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.Results:Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4263 (19.7%), and 6622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients, and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, American Society of Anesthesiologists physical status class, surgical setting, operative approach, and Nassar operative difficulty grade were identified as the 5 predictors demonstrating the highest relative importance in predicting postoperative complications.Conclusions:This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.