Elastomeric Electrospun Polyurethane Scaffolds: The Interrelationship Between Fabrication Conditions, Fiber Topology, and Mechanical Properties

Abstract

Elastomeric electrospun construct fabrication conditions are evaluated with regards to their effect on fiber topology and biaxial mechanical response. It is determined that fiber alignment alone is insufficient to predict mechanical response. Moreover, fiber intersection density is introduced as a quantifiable structural measure which can be manipulated to achieve mechanical anisotropy similar to that of native soft tissues.