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ALDO DI LEONARDO

Curriculum e ricerca

Insegnamenti

Anno accademico Codice della materia Nome della materia CFU Corso di studi
2020/2021 13842 GENETICA CON ESERCITAZIONI 9 SCIENZE BIOLOGICHE
2020/2021 21186 METODOLOGIE GENETICHE (MODULO) 3 BIOLOGIA MOLECOLARE E DELLA SALUTE
2020/2021 21261 METODOLOGIE GENETICHE E CITOGENETICHE 6 BIOLOGIA MOLECOLARE E DELLA SALUTE

Pubblicazioni

Data Titolo Tipologia Scheda
2020 P14ARF: The absence that makes the difference Articolo in rivista Vai
2020 Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents Articolo in rivista Vai
2020 Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons Articolo in rivista Vai
2020 Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon Contributo in atti di convegno pubblicato in rivista Vai
2020 Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems Articolo in rivista Vai
2020 Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature Articolo in rivista Vai
2019 Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor Articolo in rivista Vai
2019 Caffeine boosts Ataluren's readthrough activity Articolo in rivista Vai
2019 Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) Review essay (rassegna critica) Vai
2018 Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense Proceedings (TIPOLOGIA NON ATTIVA) Vai
2018 The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion Proceedings (TIPOLOGIA NON ATTIVA) Vai
2018 OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS Brevetto Vai
2018 NOTCH3 expression is linked to breast cancer seeding and distant metastasis Articolo in rivista Vai
2018 Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs Proceedings (TIPOLOGIA NON ATTIVA) Vai
2018 Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs Articolo in rivista Vai
2018 Identification of a new molecule with readthrough activity to rescue CFTR protein function Proceedings (TIPOLOGIA NON ATTIVA) Vai
2017 Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2016 p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis Articolo in rivista Vai
2016 DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy Articolo in rivista Vai
2016 Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2016 Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening Articolo in rivista Vai
2015 Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2015 Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives Articolo in rivista Vai
2015 Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons Articolo in rivista Vai
2015 Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2014 The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Articolo in rivista Vai
2014 Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2014 Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death Articolo in rivista Vai
2014 Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach Proceedings (TIPOLOGIA NON ATTIVA) Vai
2014 Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay Articolo in rivista Vai
2013 PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene Proceedings (TIPOLOGIA NON ATTIVA) Vai
2013 Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach Proceedings (TIPOLOGIA NON ATTIVA) Vai
2013 Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2013 AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) Proceedings (TIPOLOGIA NON ATTIVA) Vai
2013 PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS Proceedings (TIPOLOGIA NON ATTIVA) Vai
2012 X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2012 Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells Articolo in rivista Vai
2012 p14ARF re-expression induces apoptosis in aneuploid HCT116 cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2011 DNMT1 SILENCING ELICITS DIFFERENT CELL CYCLE RESPONSES IN PRIMARY VERSUS TUMOR CELLS AND IS ASSOCIATED WITH ANEUPLOIDY GENERATION Tesi di dottorato pre 2013 Vai
2011 PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2011 MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. Articolo in rivista Vai
2011 DNMT1 depletion activates a pathway p14ARF/TP53 controlled that induces G1 arrest preventing DNA demethylation and aneuploidy Proceedings (TIPOLOGIA NON ATTIVA) Vai
2010 Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. Articolo in rivista Vai
2010 Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2010 Bypass of G1 arrest induced by DNMT1 posttranscriptional silencing triggers aneuploidy in human cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2009 pRb loss and chromosomal instability in human cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2009 DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2009 CENPA overexpression promotes genome instability in pRb-depleted human cells. Articolo in rivista Vai
2009 Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast Proceedings (TIPOLOGIA NON ATTIVA) Vai
2009 “DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, Proceedings (TIPOLOGIA NON ATTIVA) Vai
2009 RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation Articolo in rivista Vai
2009 RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2008 Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells Articolo in rivista Vai
2008 The retinoblastoma paradigm revisited Articolo in rivista Vai
2008 AURKA (aurora kinase A) Articolo in rivista Vai
2008 Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2008 Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2008 DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations Proceedings (TIPOLOGIA NON ATTIVA) Vai
2008 Missing evidences in cancer genetics: The retinoblastoma paradigm. Articolo in rivista Vai
2007 Does the evidence matter in medicine? The retinoblastoma paradigm. Articolo in rivista Vai
2007 Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype Articolo in rivista Vai
2007 Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2007 Retinoblastoma epidemiology: Does the evidence matter? Articolo in rivista Vai
2007 Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2007 Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2006 RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts Articolo in rivista Vai
2005 Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts Articolo in rivista Vai
2005 Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 Proceedings (TIPOLOGIA NON ATTIVA) Vai
2005 Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts Proceedings (TIPOLOGIA NON ATTIVA) Vai
2004 Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 Proceedings (TIPOLOGIA NON ATTIVA) Vai
2002 Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block Articolo in rivista Vai
2001 Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants Articolo in rivista Vai
2001 The sea urchin sns insulator blocks CMV enhancer following integration in human cells Articolo in rivista Vai