| 2020 |
P14ARF: The absence that makes the difference |
Articolo in rivista |
Vai |
| 2020 |
Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents |
Articolo in rivista |
Vai |
| 2020 |
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons |
Articolo in rivista |
Vai |
| 2020 |
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon |
Contributo in atti di convegno pubblicato in rivista |
Vai |
| 2020 |
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems |
Articolo in rivista |
Vai |
| 2020 |
Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature |
Articolo in rivista |
Vai |
| 2019 |
Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor |
Articolo in rivista |
Vai |
| 2019 |
Caffeine boosts Ataluren's readthrough activity |
Articolo in rivista |
Vai |
| 2019 |
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) |
Review essay (rassegna critica) |
Vai |
| 2018 |
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2018 |
The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2018 |
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS |
Brevetto |
Vai |
| 2018 |
NOTCH3 expression is linked to breast cancer seeding and distant metastasis |
Articolo in rivista |
Vai |
| 2018 |
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2018 |
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs |
Articolo in rivista |
Vai |
| 2018 |
Identification of a new molecule with readthrough activity to rescue CFTR protein function |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2017 |
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2016 |
p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis |
Articolo in rivista |
Vai |
| 2016 |
DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy |
Articolo in rivista |
Vai |
| 2016 |
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2016 |
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening |
Articolo in rivista |
Vai |
| 2015 |
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2015 |
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives |
Articolo in rivista |
Vai |
| 2015 |
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons |
Articolo in rivista |
Vai |
| 2015 |
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2014 |
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. |
Articolo in rivista |
Vai |
| 2014 |
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2014 |
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death |
Articolo in rivista |
Vai |
| 2014 |
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2014 |
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay |
Articolo in rivista |
Vai |
| 2013 |
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2013 |
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2013 |
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2013 |
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2013 |
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2012 |
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2012 |
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells |
Articolo in rivista |
Vai |
| 2012 |
p14ARF re-expression induces apoptosis in
aneuploid HCT116 cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2011 |
DNMT1 SILENCING ELICITS DIFFERENT CELL CYCLE RESPONSES IN PRIMARY VERSUS TUMOR CELLS AND IS ASSOCIATED WITH ANEUPLOIDY GENERATION |
Tesi di dottorato pre 2013 |
Vai |
| 2011 |
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2011 |
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. |
Articolo in rivista |
Vai |
| 2011 |
DNMT1 depletion activates
a pathway p14ARF/TP53
controlled that induces G1 arrest
preventing DNA demethylation
and aneuploidy |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2010 |
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. |
Articolo in rivista |
Vai |
| 2010 |
Identification of mechanism(s) leading to
hyperdiploidy in progenitor tumor cells derived
from MCF7 breast cancer cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2010 |
Bypass of G1 arrest induced by DNMT1 posttranscriptional
silencing triggers aneuploidy in
human cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2009 |
pRb loss and chromosomal instability in human cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2009 |
DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2009 |
CENPA overexpression promotes genome instability in pRb-depleted human cells. |
Articolo in rivista |
Vai |
| 2009 |
Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2009 |
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2009 |
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation |
Articolo in rivista |
Vai |
| 2009 |
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2008 |
Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells |
Articolo in rivista |
Vai |
| 2008 |
The retinoblastoma paradigm revisited |
Articolo in rivista |
Vai |
| 2008 |
AURKA (aurora kinase A) |
Articolo in rivista |
Vai |
| 2008 |
Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2008 |
Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2008 |
DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2008 |
Missing evidences in cancer genetics: The retinoblastoma paradigm. |
Articolo in rivista |
Vai |
| 2007 |
Does the evidence matter in medicine? The retinoblastoma paradigm. |
Articolo in rivista |
Vai |
| 2007 |
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype |
Articolo in rivista |
Vai |
| 2007 |
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2007 |
Retinoblastoma epidemiology: Does the evidence matter? |
Articolo in rivista |
Vai |
| 2007 |
Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2007 |
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2006 |
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts |
Articolo in rivista |
Vai |
| 2005 |
Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts |
Articolo in rivista |
Vai |
| 2005 |
Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2005 |
Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2004 |
Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 |
Proceedings (TIPOLOGIA NON ATTIVA) |
Vai |
| 2002 |
Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block |
Articolo in rivista |
Vai |
| 2001 |
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants |
Articolo in rivista |
Vai |
| 2001 |
The sea urchin sns insulator blocks CMV enhancer following integration in human cells |
Articolo in rivista |
Vai |
