Transbuccal delivery of l-dopa methyl ester: ex vivo permeation studies
- Autori: De Caro, V.; Scaturro, A.L.; Giandalia, G.; Siragusa, M.G.; Sutera, F.M.; Campisi, G.; Florena, A.M.; Wolff, A.; Giannola, L.I.
- Anno di pubblicazione: 2012
- Tipologia: Abstract in atti di convegno pubblicato in volume
- OA Link: http://hdl.handle.net/10447/62803
Abstract
Introduction Despite the efforts directed towards augmenting dopaminergic function in Parkinson Disease (PD), there remains an unmet need to reduce in patients delayed time of motor fluctuations and diskynesia. Peroral administration of conventional medications do not resolve this problem and it may be necessary to use alternative delivery routes