Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration
- Autori: Tusch, E.; Ryom, L.; Pelchen-Matthews, A.; Mocroft, A.; Elbirt, D.; Oprea, C.; Günthard, H.F.; Staehelin, C.; Zangerle, R.; Suarez, I.; Vehreschild, J.J.; Wit, F.; Menozzi, M.; D'Arminio Monforte, A.; Spagnuolo, V.; Pradier, C.; Carlander, C.; Suanzes, P.; Wasmuth, J.; Carr, A.; Petoumenos, K.; Borgans, F.; Bonnet, F.; De Wit, S.; El-Sadr, W.; Neesgaard, B.; Jaschinski, N.; Greenberg, L.; Hosein, S.R.; Gallant, J.; Vannappagari, V.; Young, L.; Sabin, C.; Lundgren, J.; Peters, L.; Reekie, J.; Null, N.; El-Sadr, W.; Calvo, G.; Bonnet, F.; Dabis, F.; Kirk, O.; Mocroft, A.; Law, M.; D'Arminio Monforte, A.; Morfeldt, L.; Pradier, C.; Reiss, P.; Weber, R.; De Wit, S.; Lind-Thomsen, A.; Brandt, R.S.; Hillebreght, M.; Zaheri, S.; Wit, F.W.N.M.; Scherrer, A.; Schöni-Affolter, F.; Rickenbach, M.; Tavelli, A.; Fanti, I.; Leleux, O.; Mourali, J.; Marec, F.L.; Boerg, E.; Thulin, E.; Sundström, A.; Bartsch, G.; Thompsen, G.; Necsoi, C.; Delforge, M.; Fontas, E.; Caissotti, C.; Dollet, K.; Mateu, S.; Torres, F.; Petoumenos, K.; Blance, A.; Huang, R.; Puhr, R.; Laut, K.G.; Kristensen, D.; Sabin, C.A.; Phillips, A.N.; Kamara, D.A.; Smith, C.J.; Mocroft, A.; Hatleberg, C.I.; Lind-Thomsen, A.; Brandt, R.S.; Raben, D.; Matthews, C.; Bojesen, A.; Grevsen, A.L.; Lundgren, J.D.; Ryom, L.; Powderly, B.; Shortman, N.; Moecklinghoff, C.; Reilly, G.; Franquet, X.; Ryom, L.; Mocroft, A.; Kirk, O.; Reiss, P.; Smit, C.; Ross, M.; Fux, C.A.; Morlat, P.; Fontas, E.; Kamara, D.A.; Smith, C.J.; Lundgren, J.D.; Smith, C.J.; Ryom, L.; Hatleberg, C.I.; Phillips, A.N.; Weber, R.; Morlat, P.; Pradier, C.; Reiss, P.; Wit, F.W.N.M.; Friis-Møller, N.; Kowalska, J.; Lundgren, J.D.; Sabin, C.A.; Ryom, L.; Hatleberg, C.I.; Law, M.; D'Arminio Monforte, A.; Dabis, F.; Bonnet, F.; Reiss, P.; Wit, F.W.N.M.; Smith, C.J.; Kamara, D.A.; Bohlius, J.; Bower, M.; Fätkenheuer, G.; Grulich, A.; Lundgren, J.D.; Sjøl, A.; Meidahl, P.; Iversen, J.S.; Reiss, C.P.; Zaheri, S.; Hillebregt, M.; Wit, F.W.N.M.; Prins, J.M.; Kuijpers, T.W.; Scherpbier, H.J.; Van Der Meer, J.T.M.; Wit, F.W.N.M.; Godfried, M.H.; Reiss, P.; Van Der Poll, T.; Nellen, F.J.B.; Geerlings, S.E.; Van Vugt, M.; Pajkrt, D.; Bos, J.C.; Wiersinga, W.J.; Van Der Valk, M.; Goorhuis, A.; Hovius, J.W.; Van Eden, J.; Henderiks, A.; Van Hes, A.M.H.; Mutschelknauss, M.; Nobel, H.E.; Pijnappel, F.J.J.; Jurriaans, S.; Back, N.K.T.; Zaaijer, H.L.; Berkhout, B.; Cornelissen, M.T.E.; Schinkel, C.J.; Thomas, X.V.; De Ruyter Ziekenhuis, A.; Van Den Berge, M.; Stegeman, A.; Baas, S.; De Looff, L.H.; Versteeg, D.; Ziekenhuis, C.; Pronk, M.J.H.; Ammerlaan, H.S.M.; De Munnik, E.S.; Jansz, A.R.; Tjhie, J.; Wegdam, M.C.A.; Deiman, B.; Scharnhorst, V.; Van Der Plas, A.; Weijsenfeld, A.M.; Van Der Ende, M.E.; De Vries-Sluijs, T.E.M.S.; Van Gorp, E.C.M.; Schurink, C.A.M.; Nouwen, J.L.; Verbon, A.; Rijnders, B.J.A.; Bax, H.I.; Van Der Feltz, M.; Bassant, N.; Van Beek, J.E.A.; Vriesde, M.; Van Zonneveld, L.M.; de Oude-Lubbers, A.; van den Berg-Cameron, H.J.; Bruinsma-Broekman, F.B.; De Groot, J.; De Man, M.D.Z.; Boucher, C.A.B.; Koopmans, M.P.G.; Van Kampen, J.J.A.; Pas, S.D.; Mc–sophia, E.; Driessen, G.J.A.; Van Rossum, A.M.C.; Van Der Knaap, L.C.; Visser, E.; Branger, J.; Rijkeboer-Mes, A.; De Ven, C.J.H.M.D.; Ziekenhuis, H.; Schippers, E.F.; Van Nieuwkoop, C.; Van Ijperen, J.M.; Geilings, J.; Van Der Hut, G.; Franck, P.F.H.; Van Eeden, A.; Brokking, W.; Groot, M.; Elsenburg, L.J.M.; Damen, M.; Kwa, I.S.; Groeneveld, P.H.P.; Bouwhuis, J.W.; Van Den Berg, J.F.; Van Hulzen, A.G.W.; Van Der Bliek, G.L.; Bor, P.C.J.; Bloembergen, P.; Wolfhagen, M.J.H.M.; Ruijs, G.J.H.M.; Kroon, F.P.; De Boer, M.G.J.; Bauer, M.P.; Jolink, H.; Vollaard, A.M.; Dorama, W.; Van Holten, N.; Claas, E.C.J.; Wessels, E.; Den Hollander, J.G.; Pogany, K.; Roukens, A.; Kastelijns, M.; Smit, J.V.; Smit, E.; Struik-Kalkman, D.; Tearno, C.; Bezemer, M.; Van Niekerk, T.; Pontesilli, O.; Lowe, S.H.; Lashof, A.M.L.O.; Posthouwer, D.;
- Anno di pubblicazione: 2024
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/696463
Abstract
Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.