Time-Resolved Information-Theoretic and Spectral Analysis of fNIRS Signals from Multi-Channel Prototypal Device

Abstract

Functional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique that measures brain hemodynamic activity by detecting changes in oxyhemoglobin and deoxyhemoglobin concentrations using light in the near-infrared spectrum. This study aims to provide a comprehensive characterization of fNIRS signals acquired with a prototypal continuous-wave fNIRS device during a breath-holding task, to evaluate the impact of respiratory activity on scalp hemodynamics within the framework of Network Physiology. To this end, information-theoretic and spectral analysis methods were applied to characterize the dynamics of fNIRS signals. In the time domain, time-resolved information-theoretic measures, including entropy, conditional entropy and, information storage, were employed to assess the complexity and predictability of the fNIRS signals. These measures highlighted distinct informational dynamics across the breathing and apnea phases, with conditional entropy showing a significant modulation driven by respiratory activity. In the frequency domain, power spectral density was estimated using a parametric method, allowing the identification of distinct frequency bands related to vascular and respiratory components. The analysis revealed significant modulations in both the amplitude and frequency of oscillations during the task, particularly in the high-frequency band associated with respiratory activity. Our observations demonstrate that the proposed analysis provides novel insights into the characterization of fNIRS signals, enhancing the understanding of the impact of task-induced peripheral cardiovascular responses on NIRS hemodynamics.