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Discipline Chirurgiche, Oncologiche e Stomatologiche

Research activity

The research activity of the Department is based on the following Research Projects funded by different bodies both at European and National level:

  • Hypoxia, inflammation and redox status as determinants of malignant progression of cancer stem cells - RF-2011-02349126, Scientific coordinator Dr. Marco Tafani
  • High-speed label-free broadband vibrational imaging of lipid biomolecules in cells and organotypic cultures funded entirely by King Abdullah University of Science and Technology (KAUST)
  • PON Research and Competitiveness 2007-2013 / FESR European General Development Fund
    • Identification of biomarkers and development of diagnostic and therapeutic methods in the field of oncology and vascular biology
    • Development of targeted therapeutic technologies and reduced side effects
  • FIRB
    • Ex vivo evaluation of targeted therapies against tyrosine kinase receptor MET: Identification of genetic and biological determinants for prediction of treatment efficacy
    • Development of new antitumor therapeutic strategies based on proteomic investigations of the signal transduction pathways relevant to cancer stem cells
  • AIRC 5Xmille Molecular Clinical Oncology Extension Program
    • Development of effective cancer therapy based on functional proteomics and cancer stem cells targeting.
  • AIRC
    • IG 2015 Molecular mechanisms underlying thyroid cancer metastasis: emergence from tumor dormancy
    • Molecular events underlying the metastatic potential of breast cancer stem cells
    • Oncogene-driven transformation: Normal versus Cancer Stem Cells
  • CORI
    • Study of micro-RNAs associated with hypoxia in breast cancer - action B
    • International collaboration with Université Laval Center de Recherche du Chul - Foreign scholar visit Calvo Ezequiel Luis - Action D
  • FFR - Ex 60%
    • Use of autologous mesenchymal stem cells in organ and tissue insufficiency - experimental study on animal model
    • Use of Prostacyclin in Microsurgery
    • Molecular profiles in male breast cancer (Male Breast Cancer, MBC)
    • Feasibility and predictive parameters of transcutaneous oximetry in limb rescue of diabetic patients with critical ischemia of lower limbs
    • Assisted software evaluation of the angiogenic phenomenon of the oral mucosa during oral and systemic pathologies, in patients exposed to risk factors (smoking, alcohol) and during dental treatments (orthodontic, surgical, implant and endodontic).
    • Analysis of gene polymorphisms and copy number variation (CNV), and identification of a gene and miRNA signature in patients affected by gastrointestinal stromal tumors (GIST): Diagnostic, prognostic, predictive role.
    • Role of HPV nasosinusal infections in the pathogenesis of syndromic polyposis and their evolution
    • Molecular mechanisms involved in breast cancer progression
    • Role of microRNAs in the pathogenesis of Barrett's Esophagus and esophageal carcinoma
    • Circulating levels of follistatin in therapeutic monitoring and follow-up of patients with bone metastases
    • Complaints system and accusatory process
    • Detection of micronuclei as damage to DNA in different pathologies of the oral mucosa and glands attached to the stomatognathic apparatus
    • Endoscopic diagnosis of Barrett's esophagus with chromoendoscopy
    • Role of phosphoproteins in the chemoresistance of colon cancer stem cells
    • Tumor stem cells of epithelial tumors: identification of new molecular targets involved in the processes of tumor progression, metastasis and chemoresistance
    • Comparison between cpRMN and ERCP in the diagnosis of benign and malignant diseases of the bilio-pancreatic pathways. Retrospective and prospective evaluation
    • Study of the role of mutations in the BRCA1 and 2 genes in patients with breast and ovarian cancer
    • Periodontal health in menopausal women undergoing hormone replacement therapy
    • The evolution of the criminal procedural system in the light of the jurisprudence of the Court of Strasbourg
    • Analysis of genomic and mitochondrial DNA instability in patients with gastric cancer
    • Predictive value of serum levels of the "Vascular Endothelial Growth Factor" (VEGF) in cancer patients treated with antiangiogenic drugs and prognostic correlation with the blood levels of Dimer D (DD).
    • Anatomical study of the artery and facial vein perforating vessels
    • Molecular and immunocytochemical analysis of ultrasound-guided needle aspiration of breast lesions in subjects at risk for the development of breast cancer
    • Evaluation of the incidence and frequency of some polymorphisms of interleukin 1 in a group of subjects with "burning mouth syndrome"
    • The penal process in application practice.
    • Study in hip arthrosis on the efficacy of ultrasound-guided infiltrations of hyaluronic acid, whether or not associated with rehabilitation treatment
    • The combined approach at one time in the treatment of multifocal hepatocarcinoma on liver cirrhosis
    • Nerve injury caused by the use of energy-based surgical instruments: experimental model for comparing different devices
    • Morphofunctional polymorphisms of the non-atherosclerotic degenerative aneurysms of the ascending aorta: anatomo-clinical study of aortic surgical explants
    • Analysis of the variation of the number of gene copies in the germ line of patients with sporadic pancreatic adenocarcinoma
    • Breast cancer stem cells and new tracers for early diagnosis.
    • Evaluation by microtensile test and scanning electron microscope (SEM) analysis of a new total-etch self-priming adhesive system applied to the dentine of deciduous teeth
    • Regulatory mechanisms of the VEGF and Leptin genes in colon carcinoma cells.
    • Features of the Dentin Substrate and Materials in Post-endodontic Conservative Adhesive Restoration
    • Phase II study on the use of weekly Docetaxel + Metronomic Capecitabine as the first line of chemotherapy in patients with metastatic gastric cancer with low performance status: correlation between response to treatment and VEGF expression.
    • The role of metalloproteinase inhibitors in laparoceles
    • Serum levels of apoptosis markers Survivina, Fas and Fas Ligando in breast cancer
    • Cathepsina. Bone metastases
    • Rational shock wave (ESWT) in plantar fasciitis with heel spurs
    • Study of the main single nucleotide polymorphisms in patients with colorectal carcinoma and subjected to 5-FU treatment
    • Videocapillaroscopic investigation of the oral mucosa in patients with connective tissue disorders
    • Cricopharyngeal myotomy in the functional pathology of the UES: selection criteria of the candidates
    • Procedural system and precautionary appeals: the innovations between "emergency" and "guaranty"
    • Instrumental neuromuscular evaluation in patients undergoing prosthetic rehabilitation.
    • Temperature changes within the root canal during endodontic and conservative procedures
    • Immunohistochemical evaluation of COX-2 expression on colo-rectal neoplasm tissue and on healthy tissue in subjects suffering from colorectal Ca. and, subsequently, during the follow-up of operated subjects: possible correlation with clinical-pathological parameters and consequent potential use as a prognostic and relapse marker.
    • Effects of two polyphenol blends extracted from extra virgin olive oil on HL60 promyelocytic leukemia sensitive and resistant to antiblastic drugs
    • Estrogenic receptors in benign colon tumors
    • The system of criminal appeals from the 1988 code to the current structure, after the legislative changes (L. n. 46 of 2006) and the jurisprudential interpretations
    • Ultrasound applications in the diagnosis of osteoporosis and correlation with fracture risk factors
    • Experimental study on the translucency phenomenon in determining the color and aesthetics of natural teeth and in prosthetic rehabilitations.
    • Electromyographically guided physiotherapy in dysfunctions and dysmorphoses - of the craniofacial district
    • Study of the role of antibiotics in the control of bone inflammatory phenomena before and after the extraction of third molars by dosing of blood cytokines
    • Osteonecrosis of the bisphosphonate jaws: cross-sectional and prospective study with secondary and tertiary prevention programming
    • Role of some markers of the acute neuroendocrine and inflammatory response in the genesis of the confusional state of the elderly patient undergoing surgery
    • Role of methylation in the regulation of microRNAs gene expression in breast cancer cell lines
    • "Gender" violence, crimes against sexual freedom and the dignity of the victim: protection in the process
    • Prospective observational study of cystic pancreatic tumors
    • Clinical and instrumental investigation on oral and extra oral causes of halitosis: correlations between periodontal disease and liver disease
    • Analysis of molecular and immunohistochemical factors conducted on biopsy samples or on pulmonary lavage fluid in subjects with increased risk of developing lung cancer
    • Outcome and incidence of complications in the different types of vascular accesses for hemodialysis
    • Expression of matrix metalloproteinases (MMPs) in normal and pathological samples of oral mucosa; immunohistochemical and gene expression analysis during the extracellular matrix remodeling process.
    • Changes in anal sphincter function and its relationship with the onset and persistence of pain in non-neoplastic proctological surgery
    • Research on the role of cytokines in dental movements in orthodontic treatment
    • Analysis of gene expression by microarray in breast cancer cell lines
    • On the modifications that regulate the acute inflammatory response in obese patients after surgery
  • PRIN
    • Saliva as a substrate for the diagnosis of celiac disease
    • Serum and saliva studies related to the determination of Human Leukocyte Antigens (HLA) associated with celiac disease and anti-transglutaminase (anti-tTG) antibodies
    • Correlation with the clinical forms of the disease and the histo-morphological aspects of the oral and intestinal mucosa
    • Integrated sampling activities of biological matrices from patients affected by oral squamous cell carcinoma, database creation and validation of salivary bio-markers by RT-PCR and RTQ-PCR
    • Haplotype analysis in families carrying the Italian founder mutation 5083del19-BRCA1
    • Clinical randomized-controlled trial for the evaluation of the efficacy of a new medical device, in the form of a spray, consisting of synthetic amino acids and sodium hyaluronate vs a compound containing only sodium hyaluronate in the treatment of radio / chemo-induced mucositis; and a randomized, controlled, placebo clinical trial to determine the effectiveness of "Low Level Laser Therapy" in the prevention and treatment of oral mucositis in patients undergoing radio and / or chemotherapy
    • Proteolysis and genes involved in the natural history and metastasization of oral squamous cell carcinoma
    • Identification of molecular markers of progression in oral squamous cell carcinoma
  • University innovative projects
    • Use of autologous mesenchymal stem cells in organ and tissue insufficiency - experimental study on animal model