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GIULIO GHERSI

C. HYSTOLITICUM RECOMBINANT COLLAGENASES AND METHOD FOR THE MANUFACTURE THEREOF

  • Authors: Bertuzzi, F; Cuttitta, A; Ghersi, G; Mazzola, S; Salamone, M; Seidita, G;
  • Publication year: 2010
  • Type: Brevetto
  • Key words: COLLAGENASES; DIABET 1; CELL TERAPY; RECOMBINANT PROTEIN;
  • OA Link: http://hdl.handle.net/10447/59868

Abstract

The present invention relates to the production of recombinant collagenases, and in particular describes a method for the production of recombinant clostridium histolyticum collagenases Col characterized by a yield higher than approximately 140 mg/l of culture of said collagenases in soluble, biologically active form, collagenases produced by this method, compositions comprising these collagenases and the use thereof.