PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data.
- Authors: GULLO, G; VASSILIADIS, A; UNFER, V; CARLOMAGNO G; CATALANO G
- Publication year: 2014
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/103417
Abstract
The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures. Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors. Metformin administration started 2 months before the ovulation induction. Alternatively a spontaneous menstruation it was induced by progestin. Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated. Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost. Few side effects.