Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
- Authors: Di Franco, Simone; Stassi, Giorgio
- Publication year: 2021
- Type: Nota o commento
- OA Link: http://hdl.handle.net/10447/521667
Abstract
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.