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ANDREA PACE

Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.

  • Authors: PALUMBO PICCIONELLO, A.; Pierro, P.; Accardo, A.; Buscemi, S.; Pace, A.
  • Publication year: 2013
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/88647

Abstract

A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.