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Computed tomography coronary angiography plaque burden in patients with suspected coronary artery disease

  • Authors: Maffei, E.; Seitun, S.; Romano, M.; Palumbo, A.; Martini, C.; Tarantini, G.; Tedeschi, C.; Weustink, A.; Mollet, N.; Arcadi, T.; Salamone, I.; Blandino, A.; LA GRUTTA, L.; Midiri, M.; Cademartiri, F.
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: plaque burden
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PURPOSE: To determine the relationship between established cardiovascular risk factors, clinical presentation and the extent of coronary artery disease (CAD), as described with computed tomography coronary angiography. MATERIAL AND METHODS: In this cross-sectional study, we included 567 symptomatic individuals without a history of CAD who consecutively underwent 64-slice computed tomography coronary angiography for evaluation of suspected CAD. We analyzed the prevalence of CAD depending on sex, age, symptoms and risk factors. RESULTS: A total of 8542 segments were analyzed. No evidence of CAD was observed in 225 patients (40%), nonsignificant CAD in 221 patients (39%) and significant CAD (luminal narrowing >50%) in the remaining 121 patients (21%). CAD increased with advancing age, significantly above 50 years (P < 0.05). Female patients had a higher prevalence of normal coronary arteries and males of significant CAD (P < 0.01). With the increase of risk factors, there was a significant increase of the significant disease (P < 0.01). Typical pain with respect to atypical pain had the strongest association with significant CAD (16 vs. 38%; P < 0.05). In multivariate analysis, the number of risk factors, age, male sex and typical pain remained strong predictors of significant CAD (P < 0.0001). CONCLUSION: Computed tomography coronary angiography may play an important role in risk stratification of patients with suspected CAD.