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Lessons from Sicilian Centenarians for Anti-Ageing Medicine. The Oxi-Inflammatory Status

  • Authors: Caruso, Calogero; Accardi, Giulia; Aiello, Anna; Calabrò, Anna; Ligotti, Mattia E; Candore, Giuseppina
  • Publication year: 2022
  • Type: Review essay (rassegna critica)
  • OA Link:


Population ageing is a great achievement of humanity, but it also represents a challenge that the Western world is currently facing, as ageing is associated with increased susceptibility to age-related inflammatory diseases. Therefore, it is necessary to fully understand the mechanisms of healthy ageing to prevent the harmful aspects of ageing. The study of long living individuals (LLIs) is a great model for trying to achieve this goal. Accordingly, the oxy-inflammatory status of Sicilian LLIs was reviewed in the present paper. Based on the reported data, anti-inflammatory and anti-oxidative stress strategies have been discussed, useful for delaying or avoiding the onset of age-related diseases, thus favouring a healthy ageing process.