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Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals

  • Authors: Siino, Valentina; Ali, Ashfaq; Accardi, Giulia; Aiello, Anna; Ligotti, Mattia E; Mosquim Junior, Sergio; Candore, Giuseppina; Caruso, Calogero; Levander, Fredrik; Vasto, Sonya
  • Publication year: 2022
  • Type: Articolo in rivista
  • OA Link:


The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.