Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine,a new ring system as potential COX inhibitor
- Authors: Migliara, O; Spanò, V; Parrino, B; Ciancimino, C; Diana, P
- Publication year: 2012
- Type: Articolo in rivista (Articolo in rivista)
- Key words: [1,2,6]Benzothiadiazocine, 1,4-dihydropyrazolo[4,3-c][1,2,6benzothiadiazocin-11(10H)one 5,5-dioxides, pyrazole, COX inhibitors
- OA Link: http://hdl.handle.net/10447/63019
Abstract
Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.