HYPERURICEMIA IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION

Abstract

Introduction: Hyperuricemia is a cardiovascular risk factor associated with oxidative stress and inflammation, conditions that are involved in the genesis of atherosclerotic disease and in the progression of ischemic heart disease to heart failure. The aim of our retrospective study is to evaluate the variations of serum uric acid level in patients with ventricular dysfunction, in order to highlight any correlations. Methods: We enrolled 118 patients. In our population we identified three groups: patients with systolic and diastolic dysfunction (ejection fraction <50% and E wave 50% and E wave50% and E wave> A wave, n = 54). All patients underwent echocardiography and laboratory test (VES, PCR and serum uric acid). Results: Patients with diastolic dysfunction with or without systolic dysfunction showed higher values of serum uric acid than patients with normal ventricular function (6.54 ± 0.72 vs. 5.42 ± 0.78, p = 0.016). The linear regression in the group of patients with systolic dysfunction, showed a inverse relationship between the two variables analyzed, so with increasing serum uric acid there is a proportional reduction of the ejection fraction. Conclusions: Patients with isolated left ventricular diastolic dysfunction and patients with systolic and diastolic dysfunction had higher uric acid levels than patients with normal ventricular function and the progressive deterioration of systolic function correlates with a gradual increase in the values of serum uric acid.