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Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects

  • Authors: Licata, G; Di Chiara, T; Licata, A; Triolo, G; Argano, C; Pinto, A; Parrinello, G; Corrao, S; Duro, G; Scaglione, R
  • Publication year: 2003
  • Type: Articolo in rivista (Articolo in rivista)
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Fifty-six young central obese patients were investigated to evaluate relationships between soluble E-selectin (sE-S), angiotensin-converting enzyme (ACE) gene polymorphism, left ventricular function and structure, and carotid morphology by determination of sE-S and ACE genotypes. Our results indicated that central obese subjects with concomitant higher levels of sE-S and ACE DD genotype may be characterized by early cardiovascular alterations and then considered a particular subset of subjects at higher risk of cardiovascular disease.