Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis
- Authors: Aprea, M.G.; Schiavetti, I.; Portaccio, E.; Ballerini, C.; Bonavita, S.; Buscarinu, M.; Calabrese, M.; Cavalla, P.; Cellerino, M.; Cordioli, C.; Dattola, V.; De Biase, S.; De Meo, E.; Fantozzi, R.; Gallo, A.; Iasevoli, L.; Karabudak, R.; Landi, D.; Lorefice, L.; Moiola, L.; Ragonese, P.; Ruscica, F.; Sen, S.; Sinisi, L.; Signoriello, E.; Toscano, S.; Verrengia, E.; Siva, A.; Masciulli, C.; Sormani, M.P.; Amato, M.P.
- Publication year: 2024
- Type: Articolo in rivista
- Key words: COVID-19; fetal outcomes; maternal outcomes; Multiple sclerosis; pregnancy; SARS-CoV-2 infection;
- OA Link: http://hdl.handle.net/10447/639554
Abstract
Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.