Synthesis and biological evaluation of new indazole derivatives
- Authors: Plescia,S; Raffa, D; Plescia, F; Casula, G; Maggio, B; Daidone, G; Raimondi, MV; Cusimano, MG; Bombieri, G; Meneghetti, F
- Publication year: 2010
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/50878
Abstract
New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2-aminobenzamido)indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal X-ray analysis confirms the N-ethylation position for the 3-(1-ethyl-1H-indazol-3-yl)-2-phenylquinazolin-4(3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, their antiproliferative activity and their COX inhibitory activities showing scarce or moderately antiproliferative activity and some inhibitory activity against COX-1 and COX-2.