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MARIA VALERIA RAIMONDI

Pharmaceutical potential of synthetic and natural pyrrolomycins

  • Authors: Cascioferro, S.; Raimondi, M.; Cusimano, M.; Raffa, D.; Maggio, B.; Daidone, G.; Schillaci, D.
  • Publication year: 2015
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Antibiofilm agents; Antibiotic resistance; Pentabromopseudilin; Pyoluteorin; Pyrrolomycins;
  • OA Link: http://hdl.handle.net/10447/195177

Abstract

The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.