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GIORGIO ROMANO

Role and clinical importance of Helicobacter pylori infection in hemodialysis patients

  • Authors: GIOÈ, FP;CUDIA, B; ROMANO, G; COCCHIARA, G; LI VECCHI, V; GIOÈ, MA; CALÃŒ, C; LO COCO, L; ROMANO, M; Li Vecchi, M.
  • Publication year: 2008
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Helicobacter pylori, hemodialysis
  • OA Link: http://hdl.handle.net/10447/35940

Abstract

Dyspepsia is an extrarenal symptom frequently found in hemodialysed patients; it is due to chronic renal failure, and uremic gastritis is a specific associated condition in chronic renal failure (CRF). On the other hand, in the general population, Helicobacter pylori infection is an important dyspepsia-related risk factor; its close connections with gastro-duodenal pathology are already known, above all the peptic disease in a really exclusive way. By observation of a dyalitic group of patients, opportunely matched with a no CRF group, we evaluated CRF-associated uremia and Helicobacter pylori infection which could eventually interact causing symptoms and lesions. A statistical analysis of obtained data allowed us to conclude that, although there is not, from an epidemiological view-point, a larger diffusion of Helicobacter pylori among dyalitic patients compared to general population, moreover the infection is uremia-synergic in causing gastro-duodenal symptoms and lesions. These findings, therefore, suggest systematically investigation a possible Helicobacter pylori infection in CRF patients and its relation to gastritis grading, and searching for probable active peptic lesions.