First-generation antipsychotics and QTc: any role for mediating variables?
- Authors: Carra G.; Crocamo C.; Bartoli F.; Lax A.; Tremolada M.; Lucii C.; Martinotti G.; Nose M.; Bighelli I.; Ostuzzi G.; Castellazzi M.; Clerici M.; Barbui C.; Acciavatti T.; Adamo A.; Aguglia A.; Albanese C.; Baccaglini S.; Bardicchia F.; Barone R.; Barone Y.; Bergamini C.; Bertolini F.; Bolognesi S.; Bordone A.; Bortolaso P.; Bugliani M.; Calandra C.; Calo S.; Cardamone G.; Caroleo M.; Carra E.; Carretta D.; Chiocchi L.; Cinosi E.; Corbo M.; Corsi E.; Costanzo R.; Costoloni G.; D'Arienzo F.; Debolini S.; De Capua A.; Di Napoli W.A.; Dinelli M.; Facchi E.; Fargnoli F.; Fiori F.; Franchi A.; Gardellin F.; Gastaldon C.; Gazzoletti E.; Ghio L.; Giacomin M.; Gregis M.; Iovieno N.; Koukouna D.; Lintas C.; Luca A.; Luca M.; Lussetti M.; Madrucci M.; Magnani N.; Magni L.; Manca E.; Martorelli C.; Mattafirri R.; Paladini C.; Papola D.; Percudani M.; Perini G.; Petrosemolo P.; Pezzullo M.; Piantanida S.; Pinna F.; Prato K.; Prestia D.; Quattrone D.; Reggianini C.; Restaino F.; Ribolsi M.; Rinosi G.; Rizzo C.; Rizzo R.; Roggi M.; Rossi G.; Rossi S.; Ruberto S.; Santi M.; Santoro R.; Sepede G.; Signorelli M.S.; Soscia F.; Sozzi F.; Staffa P.; Stilo M.; Strizzolo S.; Suraniti F.; Tavian N.; Tortelli L.; Tosoni F.; Valdagno M.; Zanobini V.
- Publication year: 2016
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/639039
Abstract
Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.