HYDROGELS OF HYALURONIC ACID AND alpha, beta-POLYASPARTYLHYDRAZIDE AND THEIR BIOMEDICAL AND PHARMACEUTICAL USES
- Authors: Giammona, G.; Pitarresi, G.; Palumbo, F.
- Publication year: 2005
- Type: Brevetto
- OA Link: http://hdl.handle.net/10447/20554
Compositions and products based on the chemical crosslinking of hyaluronic acid with a polyfunctional polymer having a protein-like structure, bearing hydrazido pendent groups along the polymeric chain. The polymer is preferably, alpha-beta-polyaspartylhydrazide, a biocompatible macromolecule. The materials obtained after crosslinking, specifically hydrogels, undergo a reduced chemical and enzymatic degradation, unlike the starting hyaluronic acid, and they can be used to prepare systems for applications in the biomedical and pharmaceutical field.