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ETTORE PIRO

Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation

  • Authors: Schierz, I.; Pinello, G.; Piro, E.; Giuffre, M.; Cimador, M.; Corsello, G.
  • Publication year: 2020
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/390417

Abstract

Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.