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Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine,a new ring system as potential COX inhibitor

  • Authors: Migliara, O; Spanò, V; Parrino, B; Ciancimino, C; Diana, P
  • Publication year: 2012
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: [1,2,6]Benzothiadiazocine, 1,4-dihydropyrazolo[4,3-c][1,2,6benzothiadiazocin-11(10H)one 5,5-dioxides, pyrazole, COX inhibitors
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Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.