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Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry

  • Authors: Barbara Parrino; Stella Cascioferro; Daniela Carbone; Camilla Pecoraro; Girolamo Cirrincione; Patrizia Diana
  • Publication year: 2022
  • Type: Capitolo o Saggio
  • OA Link:


This chapter deals with 1,3-diheterocines, eight-membered heterocyclic systems with two heteroatoms, N, O and S, in a 1,3 relationship, exhibiting biological properties and exhaustively covers the literature from 2007 to the end of November 2019. The biological results of 1,3-diazocines, 1,3-oxazocines, 1,3-dioxocins and 1,3-thiazocines, that are the largest class of 1,3-diheterocines, were collected together with the few results available for 1,3-oxathiocin and 1,3-dithiocin derivatives at that time.