Skip to main content
Passa alla visualizzazione normale.


An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

  • Authors: Cascioferro, S.; Parrino, B.; Spano', V.; Carbone, A.; Montalbano, A.; Barraja, P.; Diana, P.; Cirrincione, G.
  • Publication year: 2017
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link:


The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.