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Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives

  • Authors: Cascioferro, S.; Parrino, B.; Spano', V.; Carbone, A.; Montalbano, A.; Barraja, P.; Diana, P.; Cirrincione, G.
  • Publication year: 2017
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link:


1,2,3-Triazines are a class of biologically active compounds that exhibit a broad spectrum of activities, including antibacterial, antifungal, antiviral, antiproliferative, analgesic and anti-inflammatory properties. This review, which covers the literature from the end of last century to 2016, treats, through a comprehensive, systematic approach, the 1,2,3-triazine and related benzo- and hetero-fused derivatives possessing antitumor activity. Their efficacy, combined with a simple synthesis confers to these molecules a great potential as scaffold for the development of antitumor compounds.