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Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

  • Authors: Parrino, B.; Ciancimino, C.; Carbone, A.; Spanò, V.; Montalbano, A.; Barraja, P.; Cirrincione, G.; Diana, P.
  • Publication year: 2015
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link:


Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).