Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity.
- Authors: Eleuteri, E; Di Stefano, A; Vallese, D; Gnemmi, I; Pitruzzella, A; Tarro Genta, F; Delle Donne, L; Cappello, F; Ricciardolo, FL; Giannuzzi, P
- Publication year: 2014
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/92244
Abstract
Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.