Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
- Authors: Sota, J.; MejÃa-Salgado, G.; Guerriero, S.; Ragab, G.; Costi, S.; Paroli, M.P.; Hinojosa-Azaola, A.; Lopalco, G.; Breda, L.; Giardini, H.A.M.; Fonollosa, A.; Chimenti, M.S.; Vitale, A.; Gaggiano, C.; Aguilar-Barrera, B.; RodrÃguez-Camelo, L.D.; Guaracha-Basañez, G.A.; Hegazy, M.T.; Dammacco, R.; Albano, V.; MartÃn-Nares, E.; Espinosa-Lugo, S.; Ghanema, M.; Morrone, M.; La Bella, S.; Cordeiro, R.A.; Carubbi, F.; Conforti, A.; Ruscitti, P.; Almaglouth, I.; Talarico, R.; Gentileschi, S.; Sfikakis, P.P.; Caggiano, V.; Piga, M.; Civino, A.; Ricci, F.; Thabet, M.; Govoni, M.; Tufan, A.; Crisafulli, F.; Sbalchiero, J.; Al-Mayouf, S.M.; Mauro, A.; Hashad, S.; Minoia, F.; Olivieri, A.N.; Tharwat, S.; Maggio, M.C.; Moshrif, A.; Sebastiani, G.D.; Opris-Belinski, D.; Hatemi, G.; Direskeneli, H.; Alibaz-Öner, F.; Fotis, L.; Hernández-RodrÃguez, J.; Conti, G.; Puttini, P.S.; Viapiana, O.; Giardina, A.; Barone, P.; Babu, K.; Amin, R.H.; Kawakami-Campos, P.A.; Gupta, V.; Iagnocco, A.; Åžahin, A.; Insalaco, A.; González-GarcÃa, A.; Batu, E.D.; Carreño, E.; Del Giudice, E.; Chighizola, C.B.; Conti, F.; Balistreri, A.; Frediani, B.; Cantarini, L.; de-la-Torre, A.; Fabiani, C.
- Publication year: 2025
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/687903
Abstract
Objectives: To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU). Methods: Predictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined. Results: A total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non-anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33). Conclusion: ME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.