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MARIANO LICCIARDI

A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION

  • Authors: CRAPARO EF; PITARRESI G; BONDI' ML; CASALETTO MP; LICCIARDI M; GIAMMONA G
  • Publication year: 2008
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: POLYMERIC NANOPARTICLES, RIVASTIGMINE, DRUG DELIVERY
  • OA Link: http://hdl.handle.net/10447/37864

Abstract

The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.