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Fibrosis staging in chronic hepatitis C: analysis of discordance between transient elastography and liver biopsy

  • Authors: Calvaruso, V; Cammà, C; Di Marco, V; Maimone, S; Bronte, F; Enea, M; Dardanoni, V; Manousou, P; Pleguezuelo, M; Xirouchakis, E; Attanasio, M; Dusheiko, G; Burroughs, AK; Craxì A
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Aminotranferases, liver fibrosis, transient elastography
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In chronic hepatitis C, transient elastography (TE) accurately identifies cirrhosis, but its ability to assess significant fibrosis (Metavir ‡ F2) is variable. Constitutional and liver disease-related factors may influence TE and here we examined the variables associated with differences. Three hundred consecutive hepatitis C virus (HCV)-RNA positive patients had biochemical tests, TE and a biopsy performed on the same day. The Dale model was used to identify the variables associated with discordance between biopsy and elastography results. In 97 patients (34.2%), TE and histo- logical assessment were discordant. Seventy-six of 286 (26.6%) had stage ‡F2 and TE < 7.1 kPa (false negative); 21 of 286 (7.3%) had stage