Skip to main content
Passa alla visualizzazione normale.


Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE) - lack of interference by iron deposition.

  • Authors: Di Marco, V; Bronte, F; Cabibi, D; Calvaruso, V; Alaimo, G; Borsellino, Z; Gagliardotto, F; Almasio, PL; Capra, M; Craxì, A
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link:


The correlation between liver stiffness, measured by transient elastography, liver fibrosis, using the histological METAVIR score, and iron overload, measured by atomic absorption spectrometry was evaluated in 56 homozygous-b-thalassaemics. Liver stiffness increased proportionally to liver fibrosis staging (r = 0Æ70; P > 0Æ001) independently of liver iron concentration (r = 0Æ01; P = 0Æ932). The area under the receiver-operating characteristic curve for prediction of cirrhosis was 0Æ997 (95% confidence interval [CI]: 0Æ925–1Æ000) with cut-off of 13 kPa with 100% sensitivity (95% CI: 69Æ0–100Æ0) and 95% specificity (95% CI: 84Æ2–99Æ3). Transient elastography is a reliable non-invasive tool for diagnosing advanced liver fibrosis in homozygous-b-thalassaemics, regardless of the degree of iron overload.