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Fibronectin type III domain-containing protein 5 rs3480 A>G polymorphism, irisin, and liver fibrosis in patients with Nonalcoholic fatty liver disease

  • Authors: Petta, S.; Valenti, L.; Svegliati-Baroni, G.; Ruscica, M.; Pipitone, R.; Dongiovanni, P.; Rychlicki, C.; Ferri, N.; Cammà, C.; Fracanzani, A.; Pierantonelli, I.; Di Marco, V.; Meroni, M.; Giordano, D.; Grimaudo, S.; Maggioni, M.; Cabibi, D.; Fargion, S.; Craxì, A.
  • Publication year: 2017
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link:


Contrasting data have been reported on the role of irisin, a novel myokine encoded by the FNDC5 gene, in NAFLD pathogenesis. We tested in patients with suspected NASH the association of FNDC5 variants, hepatic expression and circulating irisin with liver damage(F2-F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models.