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ITALIA DI LIEGRO

CLONING OF RAT-SPECIFIC LONG PCP4/PEP19 ISOFORM (LPI)

  • Authors: SALA, A; SCATURRO, M; PROIA, P; SCHIERA, G; BALISTRERI, E; ALALO-RATTENBACH, R; CRÉAU N; DI LIEGRO, I
  • Publication year: 2007
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: LPI, rat brain, Ca++/calmodulin signaling
  • OA Link: http://hdl.handle.net/10447/36893

Abstract

We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling. The novel rat-specific protein, tentatively named long PEP19 isoform (LPI), is the product of alternative splicing of the rat PCP4 gene encoding PEP19. We found that antibodies raised against the first 13 N-terminal amino acids of LPI, not present in PEP19, recognize a protein enriched in the developing rat brain.