In vitro and in vivo effect of CarboxyAmido-Triazole Orotate (CTO) on Imatinib resistant Chronic Myelogenous Leukemia cells
- Authors: Raimondo, S.; Corrado, C.; Taverna, S.; Flugy, A.; De Leo, G.; Alessandro, R.
- Publication year: 2012
- Type: Contributo in atti di convegno pubblicato in volume
- OA Link: http://hdl.handle.net/10447/120107
Abstract
Chronic myelogenous leukemia is a myeloproliferative disorder characterized by the t(9:22) (q34:q11) reciprocal translocation, resulting in the expression of the chimeric Bcr–Abl oncoprotein with constitutive tyrosine kinase activity. Deregulated Bcr–Abl induces the hyperactivation of various signalling pathways involved in cell growth, apoptosis and cell adhesion.