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ANTONIO CASCIO

Efficacy and safety of clarithromycin as treatment for Mediterranean spotted fever in children: a randomized controlled trial

  • Authors: Cascio, A.; Colomba, C.; Di Rosa, D.; Salsa, L.; di Martino, L.; TITONE LANZA DI SCALEA, L.
  • Publication year: 2001
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: clarithromycin Mediterranean spotted fever
  • OA Link: http://hdl.handle.net/10447/63391

Abstract

Fifty-one children with Mediterranean spotted fever (MSF) were randomized to receive either clarithromycin, 15 mg/kg/day orally in 2 divided doses, or chloramphenicol, 50 mg/kg/day orally in 4 divided doses, for 7 days. Mean time to defervescence was 36.7 h in the clarithromycin group and 47.1 h in the chloramphenicol group (P=.047). Clarithromycin could be an acceptable therapeutic alternative to chloramphenicol and to tetracyclines for children aged <8 years with MSF