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Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade

  • Authors: Taramasso L.; Bonfanti P.; Ricci E.; Maggi P.; Orofino G.; Squillace N.; Menzaghi B.; Madeddu G.; Molteni C.; Vichi F.; Riguccini E.; Saracino A.; Santoro C.; Guastavigna M.; Francisci D.; Di Biagio A.; De Socio G.V.; Sarchi E.; Chichino G.; Bolla C.; Bellacosa C.; Angarano G.; Saracino A.; Calza L.; Menzaghi B.; Farinazzo M.; Angioni G.; Gussio M.; Celesia B.M.; Falasca K.; Mastroianni A.; Guadagnino G.; Vichi F.; Salomoni E.; Martinelli C.; Di Biagio A.; Dentone C.; Taramasso L.; Bassetti M.; Cenderello G.; Molteni C.; Pellicano G.F.; Nunnari G.; Valsecchi L.; Cordier L.; Parisini S.; Rizzardini G.; Rusconi S.; Conti F.; Bandera A.; Gori A.; Motta D.; Puoti M.; Migliorino G.M.; Maggi P.; Martini S.; Cascio A.; Trizzino M.; Gulminetti R.; De Socio G.V.; Nofri M.; Francisci D.; Cibelli D.; Parruti G.; Madeddu G.; Mameli M.S.; Orofino G.; Guastavigna M.
  • Publication year: 2022
  • Type: Articolo in rivista
  • OA Link:


Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group – SIMOne, HIV-HY and STOPSHIV – and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9 ± 10.2 years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52–0.78) in 2011 and 0.56 (95% CI: 0.46–0.69) in 2015 compared with 2005, while BMI (kg/m2) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p < 0.0001). Conclusions: In recent years, PHIV have had a significantly improved metabolic profile compared with previously, despite increasing weight and BMI.